Tramazoline + Dexamethasone: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Nasal
Allergic rhinitis

Adult: Each metered dose contains tramazoline HCI 120 mcg and dexamethasone isonicotinate 20 mcg: 1 metered dose into each nostril bid/tid, titrated to the lowest effective dose. Up to 6 times in 24 hr. Max treatment duration: 14 days.
Child: Each metered dose contains tramazoline HCI 120 mcg and dexamethasone isonicotinate 20 mcg: <5 yr: Not recommended. 5-12 yr: 1 metered dose into each nostril up to bid. Max treatment duration: 14 days.
Elderly: Each metered dose contains tramazoline HCI 120 mcg and dexamethasone isonicotinate 20 mcg: 1 metered dose into each nostril bid/tid, titrated to the lowest effective dose. Up to 6 times in 24 hr. Max treatment duration: 14 days.

Contraindications

Infants. Lactation.

Special Precautions

Pregnancy. Not for prolonged use. Monitor height of children on prolonged treatment. Consider additional systemic corticosteroid cover during periods of stress or elective surgery if treated with doses higher than recommended.

Adverse Reactions

Burning sensation in nose, sneezing. Rebound congestion after prolonged use.

Overdosage

Symptoms: Pallor, sweating, tachycardia, anxiety. Management: Treatment is symptomatic.

Action

Description: Tramazoline is a sympathomimetic with actions similar to naphazoline. It produces a fast and long lasting decongestant effect on the nasal mucosa. Dexamethasone is a corticosteroid with anti-inflammatory and anti-allergic properties.
Pharmacokinetics:
Absorption: Dexamethasone: Readily absorbed from GI tract.
Distribution: Dexamethasone: Protein binding: 77%. Crosses placenta.
Excretion: Dexamethasone: Excreted in urine (65%).

Storage

Store below 25°C. Discard 6 mth after opening.

MIMS Class

Nasal Decongestants & Other Nasal Preparations

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